Let your provider know if they are excessive. Nitrate-Induced Headache in Patients with Stable Angina Pectoris: Beneficial Effect of Starting on a Low Dosage. In case of overdose, call the poison control helpline at 1-800-222-1222. Make sure laboratory personnel and all your doctors know you use this drug. Herbal supplements are natural, so they must be safe, right? Isosorbide mononitrate (Monoket) can cause headaches, dizziness, or lightheadedness. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. I strongly feel that there is coronary ischemia. Swallow the tablet/capsule whole - do not chew or crush it before you swallow. It is used to treat and prevent a wide range of different conditions. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. This site complies with the HONcode standard for trustworthy health information: verify here. Prescription and OTC Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. Then, there was a two-week placebo washout, after which the alternative treatment was given. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. What should I know about storage and disposal of this medication? It might help to take isosorbide mononitrate and dinitrate after meals. Accessed Sept. 7, 2022. On the other hand, the ER version can only help prevent angina. A very serious allergic reaction to this drug is rare. What special precautions should I follow? Try our Symptom Checker Got any other symptoms? Headache and weakness of left side (both arm and leg) may suggest a brain pathology. Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). Along with its needed effects, a medicine may cause some unwanted effects. Mayo Clinic; 2021. However, you should not flush this medication down the toilet. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Eur Heart J. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or to 30 mg 5-ISMN od for one week followed by 60 mg 5-ISMN od for one week. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. Using this medicine with any of the following medicines is not recommended. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Some of these interactions can be life-threatening. include protected health information. https://www.uptodate.com/contents/search. Some of these medicine interactions can be risky. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. sharing sensitive information, make sure youre on a federal Does Isosorbide Mononitrate interact with other medications? Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. B12 and folic acid is essential along with iron. About one-half of adults in the United States say they have used one or more supplements in the past 30 days. Change positions slowly until your body is used to the medication. The body tends to develop a tolerance (decreased sensitivity) to ISMN when it is used continuously over 24 hours. Cardizem may also be used for purposes not listed in this medication guide. Egton Medical Information Systems Limited. Isosorbide mononitrate: effectiveness, side effects, alternatives isosorbide mononitrate (Imdur, Ismo, Monoket) - MedicineNet See the full pregnancy warnings document. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). 7.6 out of 10 from a total of Side effects : headache, mild dizziness Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. View interaction reports for isosorbide mononitrate and the medicines listed below. Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. Do not stop taking it without consulting your doctor. This is so your doctor can check on your progress. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 8.0 out of 10 from a total of The site is secure. The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. health information, we will treat all of that information as protected health You need to take it every day in order for it to work. Things to remember when you fill your prescription. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Minimally clinically significant. 2023 eHealthMe.com. Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . Consult your doctor for more details. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. All rights reserved. Even if the medication is working, you may experience some unwanted side effects. Yes, it's good for health but don't take it excesse in amount, use once daily for 1 month then stop it or take once a weekly. The information eHealthMe analyzes includes: Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. I took this for 4 days, and my headaches were unbearable. Pregnancy:Data on the use of isosorbide mononitrate during pregnancy are insufficient to be able to assess the possible harmful effect. 41% of reviewers reported a positive effect, while 50% reported a negative effect. 88 ratings on Drugs.com. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. What are the side effects of Isosorbide Mononitrate ? The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect. Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Isosorbide mononitrate belongs to the group of medicines called nitrates. See also: aspirin side effects in more detail. Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain. Unable to load your collection due to an error, Unable to load your delegates due to an error. There are 195 drugs known to interact with isosorbide mononitrate, along with Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). eCollection 2021. Isosorbide mononitrate belongs to the group of medicines called nitrates. Check with your doctor immediately if any of the following side effects occur: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, slow, irregular, pounding, or racing heartbeat or pulse, itching, pain, redness, or swelling on the leg, numbness or tingling in the hands, feet, or lips, pain or discomfort in the arms, jaw, back, or neck, pain, tension, and weakness upon walking that subsides during periods of rest, shakiness in the legs, arms, hands, or feet, swelling of the face, fingers, feet, or lower legs, trembling or shaking of the hands or feet, vomiting of blood or material that looks like coffee grounds, Bluish-colored lips, fingernails, or palms. Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. We study 23,548 Isosorbide mononitrate users. This drug may make you dizzy. Bethesda, MD 20894, Web Policies No, that's not true all the time. This is because the tablets/capsules are specially made to release the medicine they contain in a controlled way. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Review/update the Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Talk to your doctor about the possible risks of using this medication for your condition. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Journals of the American College of Cardiology. Isosorbide mononitrate (Monoket) can cause some serious health issues. If it is within 2 hours of the next dose, skip the missed dose. Natural remedies for depression: Are they effective? Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. All rights reserved. If you suffer headaches when taking Isosorbide mononitrate, be patient. This site complies with the HONcode standard for trustworthy health information: verify here. Isosorbide mononitrate (Monoket) may interact with certain medications or supplements. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. What special dietary instructions should I follow? [2] Please see a good cardiologist, get admitted, get checked thoroughly. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. View World Anti-Doping Agency classifications, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves - Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures - Prophylaxis. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . Conclusions: 67% of reviewers reported a positive effect, while 13% reported a negative effect. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. A single copy of these materials may be reprinted for noncommercial personal use only. Background: Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. Isosorbide dinitrate dose 30-120 mg daily in divided doses. You can take your doses either before or after meals. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Zhonghua Yi Xue Za Zhi (Taipei). Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. Evening primrose. This makes it easier for your heart to pump, relieving heart-related chest pain. May also be prescribed off label for Esophageal Spasm. For instance, many herbal supplements that are used often interact with the blood thinner warfarin (Jantoven). We comply with the HONcode standard for trustworthy health information. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. The effects of this exposure on a nursing infant are unknown. Using this medicine with any of the following medicines is not recommended. Portions of this document last updated: Feb. 01, 2023. Isosorbide mononitrate. . Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Higher dosages are associated with stomach irritation and Enter other medications to view a detailed report. Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. Isosorbide mononitrate Interactions - Drugs.com A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. the unsubscribe link in the e-mail. Try to keep your regular appointments with your doctor. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen.